PSYC3338 Study Guide - Midterm Guide: Synaptic Plasticity, Tau Protein, Nun Study
Document Summary
Alzheimer"s effects limbic and association cortices loss of ability to encode new memories. Amyloid-b peptide (ab) is highly toxic to neurons and go up to 70-fold in ad patients. Brain imaging can show us subtle alterations of neuronal functioning (pet or fmri). Correlated with impaired synaptic plasticity and memory. Humans undergo oligomer formation before plaque formation. (ad - brain tour) There are 3 distinct parts of the brain: Brain stem automatic functions, brain to spinal cord. All parts are nourished by blood vessels. Ad changes how electrical charges travel in the cell and nt activity. Also physical changes (brain shrinks plaques cause neuronal deaths). Plaques are clusters of protein fragments that build up between nerve cells. Tangles are twisted strands of proteins which destroy cell transport. Brain regions important to memory, thinking and planning develop plaques and tangles in ad early stages. (dana guide to ad) Victims experience frustration, anger, and fear if they are aware of the disease.
