BIOL-242 Study Guide - Quiz Guide: Pathogen-Associated Molecular Pattern, Antibody Titer, Tlr2
21 May 2020
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Chapter 21 quiz #2 | toll-like receptors, interferons, Role of toll like receptors, examples of toll-like receptors and their ligands or pamps. On the surface of the macrophage, there are certain receptors important for the function of destroying microorganisms, such as tlr-4 and tlr-2. Tlr stands for toll-like receptors; they recognize pathogen. Associated molecular patterns (pamps) of microorganisms as bacteria, viruses, parasites, fungi. Tlrs on the surface of the immune cells. Tlr-4 binds to lps // only present on outer membrane of gram (-), or pink bacteria. Tlr-2 binds to peptidoglycan // located on gram (+) bacteria (blue) Tlrs in endosome (present inside the cytoplasm) Tlr-3 binds to dsrna (double strand rna) // the genetic material of some viruses. Tlr-7 binds to ssrna (single strand rna) // the genetic material of some viruses. Tlr-9 binds to dsdna (cpg = cytosine, phosphate, guanine) // unmethylated in viruses; won"t attack our methylated human cpg, only the viruses.
