PHAR 200 Study Guide - Midterm Guide: Ace Inhibitor, Distal Convoluted Tubule, Macula Densa
Document Summary
The juxtaglomerular apparatus is a microscopic structure in the kidney named for its proximity to the glomerulus (iuxta, in latin, means: right at the level of). More specifically, it is located between the vascular pole of the renal corpuscle and the distal convoluted tubule of the same nephron. Renin secretion by the juxtaglomerular cells is inversely proportional to the nacl load delivered to the macula densa. Detection of the nacl concentration depends on nacl uptake by the. Nak2cl symporter into the macula densa cells so the administration of loop diuretics (and to a lesser extent thiazide diuretics) is associated with decreased nacl accumulation and therefore, increased renin release. To minimize this unwanted effect, loop diuretics are commonly given along with angiotensin converting enzyme (ace) inhibitors. Distal convoluted tubule: this segment is also impermeable to water. Nacl is reabsorbed by an electrically neutral, na+/cl- symporter (ncc). Unlike in the thick ascending limb of the loop of.
