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Midterm

BIOL 3113 Study Guide - Midterm Guide: Cell Membrane, Growth Factor, VimentinExam


Department
BIOL
Course Code
BIOL 3113
Professor
Barbara S
Study Guide
Midterm

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PART I - MULTIPLE CHOICE (70 points - 2 points per question). Answer each question below by placing a
circle around the letter of the response that best answers the question.
1. To which part of the Golgi do vesicles coming from the ER fuse?
a. cis Golgi network
b. trans Golgi network
c. medial Golgi cisternae
d. trans Golgi cisternae
e. any part
2. Which of the following best describes polypeptides that are released into the lumen of the ER?
a. they lack a signal sequence
b. they have a single terminal start-transfer peptide that is cleaved and left behind in the translocation channel
c. they have an internal start-transfer peptide that is secondarily released from the membrane allowing the
peptide to enter the lumen
d. they have an internal start-transfer signal but no stop-transfer signal and therefore pass completely through
the membrane into the lumen
e. they have a terminal stop-transfer peptide that anchors them to the ER membrane until they reach the
Golgi, where the peptide is cleaved
3. The action potential of nerve cells is best described as:
a. a transient depolarization of the plasma membrane caused by the opening of voltage-gated K+ channels
b. a transient polarization of the plasma membrane caused by the opening of voltage-gated K+ channels
c. a transient depolarization of the plasma membrane caused by the opening of voltage-gated Ca++ channels
d. a transient depolarization of the plasma membrane caused by the opening of voltage-gated Na+ channels
e. a signal mediated release of Ca++ from cytoplasmic stores
4. vSNARES participate directly in:
a. assembly or formation of the transport vesicles

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b. movement of the vesicle along cytoskeletal proteins
c. docking of the vesicle to the target organelle
d. uncoating of the vesicle
e. fusion of the vesicle to the target organelle
5. When a trimeric G-protein is activated by a cell-surface receptor:
a. the subunit exchanges its bound GDP for GTP
b. the GDP bound to the subunit is phosphorylated to form bound GTP
c. it dissociates to the free subunit and  subunit
d. it dissociates into an active subunit and an inactive  subunit
e. the subunit exchanges its bound GDT for GTP
6. Which of the following functions as an intracellular receptor for Ca++ ?
a. a G protein
b. protein kinase A
c. calmodulin
d. DAG
e. IP3
7. Which of the following statements about ion channels is not true?
a. most are gated
b. they are ion-specific
c. they are not continuously open
d. they can be used for active transport
e. all are true
8. Which end of a transmembrane protein is located in the cytoplasm?

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a. the amino-terminus
b. the carboxyl-terminus
c. both ends are located in the cytoplasm
d. neither end is located in the cytoplasm
e. all of the above combinations are possible, depending on the protein
9. Which one of the following compartments is not topologically equivalent to the other four?
a. lysosome
b. mitochondrion
c. endoplasmic reticulum
d. Golgi
e. secretory vesicle
10. How are transmembrane proteins inserted into the plasma membrane?
a. after being synthesized on cytoplasmic ribosomes they are inserted into the membrane by ATP-driven
transporter proteins
b. they are inserted into the membrane during synthesis on the ER and later are transported to the Golgi and
then to the plasma membrane in the membranes of vesicles
c. they are transported into the lumen of the ER during synthesis, from where they travel first to the Golgi and
then to vesicles. At the cell surface the proteins are transferred from the vesicles and inserted into the
plasma membrane by ATP-driven transporter proteins
d. they are synthesized on ribosomes attached to the plasma membrane and inserted during synthesis
e. the proteins spontaneously insert into the plasma membrane from the cytosol
11. Substances move from one topologically equivalent compartment to another:
a. by means of vesicles
b. through pores
c. through gap junctions
d. through ligand-gated channels
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