PHAR 1001 Study Guide - Midterm Guide: Mitochondrial Permeability Transition Pore, Attention Deficit Hyperactivity Disorder, Bone Marrow Suppression
Document Summary
Edcs mimic naturally occurring hormones and bind to transcription factors to gain access to the cell nucleus. Then causes inappropriate timing, inappropriate duration and prevents normal cell signaling. Receptors associated with the cell membrane are more sensitive to bpa than are the ligand activated transcription factors. This increases the plausibility of the toxic effects at low doses, which are within the range of environmentally relevant doses (human and wildlife levels of exposure). Bisphenol a causes toxicity by changing cell transduction at membrane receptors. Causes inappropriate timing, inappropriate duration, and prevents normal cell signaling. How does cyanide cause toxicity? cyanide blocks atp synthesis in the mitochondria. Increased ca in a cell blocks atp synthesis. Increases formation of ros/rns and that causes cell membrane damage. What does mptp stand for? mitochondrial permeability transition pore. Acute usually refers to one does and is a less than 24-hour exposure. Chronic exposure may be repeated small doses across a long time frame, over 3 months.
