HSC 4507 Study Guide - Final Guide: Fatty Liver, Cholestasis, Hepatotoxicity
26 Dec 2019
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Document Summary
Indirect interactions: acetylcholinesterase inhibitors block the breakdown of neurotransmitters, disruption of neurotransmitter release in presynaptic neuron (botulinum toxin, endocrine system, function maintaining homeostasis + physiological progression, diseases. Increased hormone clearance: metabolizing enzymes metabolize hormones fasters, displacement of hormones from serum binding proteins, respiratory system, function gas exchange, toxic responses. Different parts of neurons and associated diseases: axonopathy: axon responsible of conducting signal down the length of neuron, can be disrupted through chemicals that target atp production and tubulin, as well as axonal swelling. Immune complex deposition: antibody complex settles in certain tissues, like kindeys and lungs, marking them for destruction by immune system type 4, cell-mediate allergy re-exposure causes large reaction because individual has become sensitive to that chemical. Role of toxicologists in public health: job of each agency/company, u. s fish and wildlife services. Drinking water?: criteria (what is needed to protect this water?, antidegradation (how do we protect it?)
