BIOLOGY 151 Study Guide - Midterm Guide: Guanine, Dna Replication, Cyclin D
Document Summary
How changes to the system will affect living things. Be able to deduce what must have happened to produce them. Find places where models are inaccurate or incomplete, and adjust. Mitosis: segregation of genetic material in cell division models to fit observed. 1) signals are released by unattached kinetochores that cause mad to bind cdc20. 2) when all kinetochores are attached, mad is releases cdc20 which then combines with apc. 6) chromatids separate as mitosis proceeds to anaphase. 1) signals released by unattached kinetochores, prevent mad from releasing. 2) attachment of the final kinetochore causes mad to release cdc20, and apc then binds cdc20. 3) the apc/cdc20 complex adds ubiquitous to securin. 4) securin is destroyed in as soon as ubiquitous is attached, which frees. 5) separase, which is inactive as long as it is bound to securin, becomes active when securin is destroyed. 6) active separase destroys cohesion, which had been holding sister chromatid together.
