BIOLOGY 3UU3 Chapter Notes - Chapter 3: Circadian Clock, Drug Metabolism, Arntl
20 Sep 2016
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Document Summary
A wheel of time: the circadian clock, nuclear receptors, and physiology. Function of circadian clock: to proactively align internal physiology with the 24h rotation of the earth. Delineate strikingly complex connections between molecular clocks and nuclear receptor signalling pathways imply existence of large-scale circadian regulatory network coordinating a diverse array of physiological processes to maintain dynamic homeostasis. Wheel of time = molecular clocks and nuclear receptors shape an emerging perspective on design principles and biological implications of the clock-receptor signaling network. Hub of time: nuclear receptors at the core of molecular clocks circadian clocks self-sustained, robust, tunable molecular oscillators. 2 interlocked transcriptional/ post-translational feedback loops found at the core of central and peripheral clocks negative feedback loop. Bmal1/clock heterodimers activate the transcription of period genes and cryptochrome genes recognize e-box cis elements in their promoters. Per/cry complex block bmal1-clock activity inhibits transcription of their own genes second feedback loop.
