BIOLOGY 3UU3 Chapter Notes - Chapter 3: Circadian Clock, Arntl, Steroid Hormone Receptor
14 Sep 2016
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Evolution at two levels: on genes and form. King and wilson similarity between many chimps and human proteins. Evolutionary changes in anatomy are not from small molecular divergences but rather based on changes in mech- anisms controlling the expression of genes (not protein modification) Milestone for three respects: comparative genomics (large number of proteins between similar species, use of molecular data the infer evolution of form, marked the beginning of understanding the genetic basis of the origins of human traits. Non-coding and regulatory regions are often ignored in comparative genomics. Some evidence for evolution of proteins lead to divergence in vision, respiration, digestive metabolism, and host defence. Britten and davidson- gene regulation in higher organisms and its relevance in evolution. Ohno- evolution by gene duplication: gene redundancy to avoid significant impact from mutations. Allelic mutation on genetic loci cannot account for major changes in evolution. Francois jacob suggested: mutations of regulatory circuits rather than chemical structure.
