HTHSCI 2F03 Chapter Notes - Chapter 4: Peritoneum, Colonoscopy, Mitosis
26 Dec 2020
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Document Summary
Peutz-jeghers, cowden disease, familial juvenile polyposis: k-ras mutations common test on histopathological sample of resection material determines chemotherapy regime. Screening programme (bcsp: polyps can be, classic adenomas: either tubular, villous or tubulovillous. 20% rule determines this: if they are >80% villous, they are villous; if they are <20% villous they are tubular; if they are >20% villous they are tubulovillous. Can be either sessile (flat) or pedunculated (stalked) Local invasion is faster with sessile polyps. Screening: nationally administered by faecal occult blood test between 60-75yo, began in uk 2006. Presentations: anaemia (r-sided ca, rectal bleeding (l-sided ca, rectal bleeding + change in bowel habit = most predictive of ca, tenesmus, obstruction, abdo mass / pr mass. Progression from high grade dysplasia carcinoma is defined by the invasion through the muscularis mucosa into the submucosa. Macroscopic features of tumours: site of tumour, maximum tumour diameter, distance of tumour to the resection margin.
