PHAR 100 Chapter Notes - Chapter 14: Cannabis Sativa, Orthostatic Hypotension, Anandamide

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State the time of onset and duration of response to smoking marijuana. List the accepted medical and proposed medical uses of the cannabinoids. Describe the effects of short-term, low dose and high dose use. Describe the effects of chronic high dose use. Describe the degree and type of tolerance and dependence associated with cannabis. Cannabis refers to the drug-containing forms of the plant hemp, cannabis sativa. 60 compounds found in cannabis sativa are referred to as cannabinoids. 1-trans- 9-tetrahydrocannabinol (thc) is the most psychoactive agent; it accounts for most, but not all of the psychoactive effects. Common names include: marijuana, hashish, hashish oil, charas, bhang, ganja and dagga. 2700 bc to 1800 plant was used to manufacture rope, mild intoxicating effects, considered less harmful than alcohol. 1920"s to 1930"s public concern, outlaw of marijuana use, considered to be a narcotic. 1978 u sa-sponsored project to destroy cannabis crops in mexico; failed. 1980"s use of marijuana began to stabilize.

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