BIOL 1090 Chapter Notes - Chapter 12: Nuclear Pore

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18 Apr 2012
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Chapter 12 - The Nucleus of a Eukaryotic Cell
Function
1. Storage, replication and repair of genetic material
2. Expression of genetic material (transcription)
3. Ribosome biosynthesis
Structure
1. Nuclear Envelope nuclear membrane, nuclear pores, nuclear lamina
2. Nuclear Contents genetic material (chromatin), nucleoplasm, nuclear
matrix, nucleolus
The Nuclear Envelope
-2 parallel phospholipid bilayers
-outer membrane binds ribosomes, continuous with the rough endoplasmic
reticulum
-inner membrane has integral proteins that bind to the lamina
-inner membrane space continuous with the endoplasmic reticulum lumen
Function
-separates nuclear contents from the cytoplasm (separates transcription and
translation)
-provides a selective barrier that allows for limited movement of molecules
between the nucleus and cytoplasm
The Nuclear Lamina
-a thin meshwork of intermediate filaments bound to the inner membrane of
the nuclear envelope by integral membrane proteins
-provides support for the nuclear envelope, as well as attachment sites for
chromatin
Nuclear Pores
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