MICR 3230 Chapter Notes - Chapter 3: Transmembrane Domain, Disulfide, T-Cell Receptor
4 Dec 2016
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Chapter 3: receptors and signaling b and t-cell. Bind peptides in groove of membrane-bound mhc proteins. When makes contact with mhc complex on apc, 2 cells brought into close proximity of one another. The t-cell receptor is a heterodimer with variable and constant regions. 2 types of tcrs, both are heterodimers. Majority of circulating t cells have heterodimer tcrs. Bind ligands made of ag"ic peptide in groove of type i or ii mhc. These have particular localization parents (often in mucosal tissues) Ag"s from those bound by t cells. Some recognize mhc-presented peptide, others bind lipid or glycolipids presented by nonclassical mch. Tcrs, although not ig"s, are members of the ig superfamily. 2 ig-like domains, each of which contains an intrachain disulfide bond spanning 60-70 aa"s. The c domain of tcr differs from most ig domains in that it has a single sheet rather than a pair, remainder of sequence is more variably folded.
