PATH 3610 Chapter Notes - Chapter 11: Peripheral Neuropathy, Microangiopathy, Endothelium
27 Mar 2018
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Document Summary
Majority of cells in pancreas carry out exocrine functions. Production of inactive enzymes to pancreatic duct and activated in lumen of duodenum. Trypsin, chymotrypsin, aminopeptidase, elastase, amylase, lipase, phospholipase. Results in lack of absorption and cachexia result. Retention of undigested material results in diarrhea and bacterial overgrowth, gas and toxin production by bacteria. Most frequently caused by obstruction of the pancreatic duct through gallstones (choleliths) Activation of pancreatic enzymes in pancreatic tissue autodigestion. Complete destruction of pancreas (both exo and endocrine) if chronic. Lead to exocrine pancreatic insufficiency and diabetes mellitus. Production of hormones such as insulin and glucagon. Released in response to high blood glc. Storage hormone: inhibits fat breakdown (ensure energy stores are maintained by fat cells), stimulate glycogen formation in liver and muscle. Affect transmembrane transport of glc and aa. Muscle and fat require ins to use glc and affect glc transport. Blood glc above normal and maintained = degeneration of endothelial cells.
