BIOL273 Chapter Notes - Chapter 1: Dependent And Independent Variables, Endocrine System, Biorhythm
3 Feb 2013
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Clearance: volume of blood cleared of substance x per unit of time. Hepatocytes: liver cells, metabolize diff types of molecules, esp. xenobiotics > resulting metabolites may be secreted to intestine for excretion in the feces/into the blood for excretion by kidneys. Easy to monitor by taking a blood sample. Dynamic steady state: materials constantly moving back and forth between the two compartments (ecf and icf) , no net movement of materials b/t the compartments. Steady state does not mean equilibrium(same composition in two compartments but diff. concentrations of substances) e. g. na+ and cl- more oncentrated in ecf, k+ more in icf = ecf and icf exist in a state of disequilibrium. Regulated variables: key functions that has to be kept within acceptable range by physiological control if the variable strays from setpoint. Negative feedback: a pathway which response opposes or removes the signal. Response removes the stimulus thus response loop shuts off.
