CHMB41H3 Chapter 4: Textbook Notes_Chapter 4

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Constitutional isomers: differ in the way their atoms are connected. Stereoisomers: same connectivity of atoms but differ in the way their atoms are arranged in space: conformational isomers: cannot be separated (as they rapidly interconvert) Amine inversion: configurational isomers: can be separated (as they cannot interconvert unless covalent bonds are broken) Cis-trans (aka geometric) isomers result from restricted rotation that can caused by either a cyclic structure or a double bond. Rotation about a double bond only occurs if the pi bond breaks that is only if the p orbitals are no longer parallel. Cis and trans isomers can be separated from each other as they are different compounds with different physical properties such as boiling point (and have different dipole moments) 4. 2: using the e,z system to distinguish isomers. The z isomer has the high-priority groups on the same side (cis) The e isomer has the high-priority groups on the opposite sides (trans)

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