HLTA01 Ch 16

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University of Toronto Scarborough
Health Studies
Caroline Barakat

Ch 16 Plagues wo GermsSpain 1735Pellagra The Red Plague Skin rashbutterfly sign that crusts and peels awayLoss of balance weakness muttering 4 Ds dermatitis diarrhea dementia death 1863 Dr Salas thought the cause was spoiled corn infested w the parasite verdetBecame an epidemic in American South in early 1900s Highest cases among insane asylumspoorest Eradicated in 195015 Joseph Goldberg disd a lack of animal protein food red meat was the cause f a study conducted in a Mississippi prison Cotton prices fallwages fallnutrition falls inability to afford protein meatNutritionist McCollum was certain that it was contagiousundermined the idea of a dietarydeficiency diseaseGoldberg conducted filth parties to strengthen his hypothesis The cure is food w the pellagrapreventive factor PP fresh meat milk eggsveg Dried brewers yeast contained the PP factorhelped preventcure it 39 ElvejhemSpies later disd that niacin a watersoluble vitamin B was Goldbergs PP factor preventive of pellagra The Great DepressionWWII eradicated pellagra w an increase in economicsinclusion of vitamins Niacin is a product of the coenzymes NAD Nicotinamide adenine dinucleotideNADP Nicotinamide adenine dinucleotide phosphate Both enzymes are reqd for oxidative metabolism of sugars Sugars arent metabolized food cannot be used as an energy source body cells die pellagra symptomsMexicans adopt a practice of soaking corn meal in limewater allowing the niacin to be
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