PSYB65H3 Chapter Notes - Chapter 3: Dendritic Spine, Neuroglia, Schwann Cell
Document Summary
Fraternal twins alexis and noah seemingly acquired cerebral palsy perinatally: they had poor muscle tone and could barely walk or sit, noah drooled and vomited, alexis had tremors. Usually children with cerebral palsy, a condition featuring perinatal brainstem damage, do not get worse with age: but the t(cid:449)i(cid:374)s" (cid:272)o(cid:374)ditio(cid:374) dete(cid:396)io(cid:396)ated. The mother noticed that ale(cid:454)is"s s(cid:455)(cid:373)pto(cid:373)s flu(cid:272)tuated: i(cid:373)p(cid:396)o(cid:448)ed afte(cid:396) she slept. After doing some research on the case, the mom found a rare condition, dopa-responsive dystonia (dystonia means abnormal muscle tone: stems from deficiency of neurochemical, dopamine, produce by a relatively small cluster of cells in the midbrain. Alexis and noah received daily dose of i-dopa, a chemical that some brain cells convert to dopamine, they felt better after taking it. A few years later, alexis started to develop different symptoms, such as breathing difficulties. Whe(cid:374) the t(cid:449)i(cid:374)s" do(cid:272)to(cid:396)s added t(cid:396)(cid:455)ptopha(cid:374), the e(cid:374)z(cid:455)(cid:373)e that is (cid:272)o(cid:374)(cid:448)e(cid:396)ted to se(cid:396)oto(cid:374)i(cid:374), to the l- dopa, both twins showed remarkable improvement.
