PSYB65H3 Chapter Notes - Chapter 6: Cytochrome P450, Endothelium, Tight Junction
Document Summary
Chapter 6 how do drugs and hormones influence the brain & behavior. Psychopharmacology study of how drugs affect the nervous system and behavior. Drugs are chemical compounds administered to bring about some desired change in the body. Usually used to diagnose, treat or prevent illness, relive pain, etc. Blood has high water concentration. Drug must be soluble in water in blood, drug is diluted by approx. 6l of blood that circulate through body. When blood leaves bloodstream, bodys roughly 35 l of ecf further dilutes it. Drugs administered as gases penetrate the cell linings of the resp tract easily. Absorbed across membranes into bloodstream fewest obstacles encountered if psychoactive drug is injected into the brain. Body has barriers to internal movement of drugs cell membrane, capillary walls, placenta, etc. It protects brain from effect s of many circulating hormones and from various toxic and infectious substances. Brain capillaries composed of a single layer of endothelial cells.
