PSYC62H3 Chapter Notes - Chapter 4: Active Metabolite, Neurotransmitter Receptor, Radioligand
Document Summary
Pharmacokinetics, is concerned with how drugs move throughout the body. Pharmacodynamics, is concerned with how drugs cause biological changes in the body. Friday january 22nd 2016: absorption: refers to the entry of a drug into the circulatory system. Most therapeutic drugs are orally administered and most drug absorption occurs in the small intestine: distribution: the passage of a drug through the body. Bioavailability: ability of a drug to reach a site of action. Nonspecific binding: binding of a drug to sites that are not the intended target for drug effects. Eg. when the dug binds to proteins in the bloodstream, as a result drugs cannot cross the blood brain barrier. This conversion most often takes place in the liver, but can also occur in the stomach. Personalized medicine: method of prescribing drugs most appropriate for a patie(cid:374)t"s unique biological makeup. First pass metabolism: metabolism of a drug begins to occur before the drug reaches the site of action.
