PSYC62H3 Chapter Notes - Chapter 10: Opioid Receptor, Desomorphine, Oxycodone
Document Summary
Opioids: opioids psychoactive substances that elicit pharmacological effects by acting on opioid receptors, narcotic a drug with sedative effects, generally used as a synonym for opioids. Pharmacokinetic properties and opioid abuse: general routes of administration. Fentanyl, morphine: partial opioid receptor agonists drugs that produce partial agonist actions at receptors, e. g. Pentazocine/talwin: buprenorphine, acts through many mechanisms, 1. Its active metabolite, norbuprenorphine, acts as a full agonist for both and receptors: 4. Agonist for orl-1: may explain its ceiling effect for pain, different mechanisms of action produced by opioid receptors produce different discriminative stimulus effects. Opioid system interactions with reward, pain, and stress systems: reward, endogenous and exogenous opioids produce reinforcing effects by affecting dopamine and gaba neurotransmission, opioids increase dopamine release by primarily binding to opioid receptors on. Opioids inhibit the activity of gaba neurons in the vta: less gaba to activate inhibitory gaba receptors in the mesolimbic dopamine neurons, therefore more dopamine, 2.
