PSYC62H3 Chapter Notes - Chapter 9: Succinic Semialdehyde, Alcohol Dehydrogenase, Metabolic Pathway
13 Jun 2016
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Gamma-hydroxybutyrate is both a drug and a neurotransmitter that has depressant effects on the cns: white, tasteless powder. Ghb as a date rape drug, and because of this it"s a schedule i drug. Another formulation of gbh, called sodium gamma-hydroxybutyrate as a treatment for narcolepsy (excessive daytime sleepiness). Sodium oxybate is another name and it"s a schedule iii drug. Ghb can be synthesized from gbl, which is seen in paint removers. The body naturally synthesizes ghb in the cns. In 2000, the dea placed ghb on the controlled substances schedule. The availability and use of ghb declined significantly since the regulation. Ghb is both a naturally occurring substance in the cns and a synthetically produced drug. Gaba transaminase converts gaba metabolite succinic semialdehyde (ssa) Certain substances serve as prodrugs for ghb: gbl and 1,4-butanediol, these chemicals use the alcohol metabolic pathway to produce ghb, 1,4 butanediol enters the liver or the stomach and alcohol dehydrogenase converts it to gbl.
