PSYC62H3 Chapter Notes - Chapter 11: Brainstem, Medical Cannabis, Mast Cell
Document Summary
Comes from: cannabis dativa, cannabis indica, cannabis ruderalis. Trichomes- biologically released by phytocannabinoids (found in cannabis) Phytocannabis- contains 9 tetrahydrocannabinol, 8 tetrahydrocannabinol, cannabidiol, cannabinol, Marijuana- consists of dried cannabis flower, leaves, stems. Hashish- condensed preparation of cannabis that primarily contains trichome resins; contains greater. Synthetic marijuana/ herbal alternatives: laboratory-synthesized cannabinoid receptor agonists. Oral administration: pill form, creative baking: thc -- stomach, intestines liver (first-pass metabolism) 50% reduction -- brain, enzyme p450 and metabolites. Inhalation: joint, hookah, bong: 50% thc is released, most are absorb into the bloodstream -- brain. 9 thc exhibits high lipid solubility- rapid distribution into tissues in body and brain and accumulation in fat (slow release form fat causes long term action) 9 thc ahs long elimination rate; reaches peak at 4-5 days. Anandamide- not stored in vesicles; released immediately after synthesis by nape; enzyme faah converts anandamide into inactive components. Actions at cannabinoid receptors= behavioural and physiological effects of cannabinoids and endocannabinoids.
