Textbook Notes (381,223)
CA (168,408)
UTSC (19,325)
Psychology (10,054)
PSYC62H3 (333)
Chapter 3

Chapter 3 Textbook Notes

4 Pages
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Department
Psychology
Course Code
PSYC62H3
Professor
Suzanne Erb

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Chapter 3 – Pharmacokinetics
Pharmacodynamics was concerned w/ what the drug does to the body BUT pharmacokinetics is
concerned w/ what the body does to the drug
Pharmacokinetics
The dynamic processes involved in the movement of drugs within biological systems w/
respect to the drug's absorption, distribution, binding or localization in tissues, metabolic
alterations and excretion from the body.
This is what determines the difference btwn 2 drugs' potency
Depends on species, age, ethnicity, genetics, psychological status, physiological status,
maybe gender.
2 important factors in a drug's affects are it's rate of accumulation and concentration.
Drug Absorption
Depends on Solubility!
Drugs must enter the CNS to produce its' psychological effects – but drug molecules are just
too large to cross membranes
So drugs must be soluble in fat!
Lipid solubility
Drug's capability of being dissolved in fat
Most important factor in a drug's ability to pass through membranes
As drug's lipid solubility increases = better absorption from the blood = will accumulate
in tissues outside the blood = get to brain faster
So drug dissolves in blood & transported by bloodstream – but for this to happen, drugs
should also be water-soluble
Solubility in water & oil
dissolves in blood
oil/water partition coefficient
Routes of Administration
P.O. (mouth)
most common, safest, cheapest, & convenient
drug administered through the mouth so that it could be absorbed by the gastrointestinal
tract (G.I.)
What affects absorption from G.I. Tract?
Whether drug is ionized or non-ionized
Drugs are usually weak bases(alkaloids) or weak acids(acids)
Weak acid: aspirin
Alkaloids: Cocaine, heroin
Such drugs are usually administered in the form of a salt (combo of acid & base)
Salt exists in ionized & non-ionized form
ionized = non fat-soluble
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Description
Chapter 3 Pharmacokinetics Pharmacodynamics was concerned w what the drug does to the body BUT pharmacokinetics is concerned w what the body does to the drug Pharmacokinetics The dynamic processes involved in the movement of drugs within biological systems w respect to the drugs absorption, distribution, binding or localization in tissues, metabolic alterations and excretion from the body. This is what determines the difference btwn 2 drugs potency Depends on species, age, ethnicity, genetics, psychological status, physiological status, maybe gender. 2 important factors in a drugs affects are its rate of accumulation and concentration. Drug Absorption Depends on Solubility! Drugs must enter the CNS to produce its psychological effects but drug molecules are just too large to cross membranes So drugs must be soluble in fat! Lipid solubility Drugs capability of being dissolved in fat Most important factor in a drugs ability to pass through membranes As drugs lipid solubility increases = better absorption from the blood = will accumulate in tissues outside the blood = get to brain faster So drug dissolves in blood & transported by bloodstream but for this to happen, drugs should also be water-soluble Solubility in water & oil dissolves in blood oilwater partition coefficient Routes of Administration P.O. (mouth) most common, safest, cheapest, & convenient drug administered through the mouth so that it could be absorbed by the gastrointestinal tract (G.I.) What affects absorption from G.I. Tract? Whether drug is ionized or non-ionized Drugs are usually weak bases(alkaloids) or weak acids(acids) Weak acid: aspirin Alkaloids: Cocaine, heroin Such drugs are usually administered in the form of a salt (combo of acid & base) Salt exists in ionized & non-ionized form ionized = non fat-soluble www.notesolution.com
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