Textbook Notes (362,773)
Canada (158,052)
Psychology (9,545)
PSYC62H3 (273)
Chapter 2&6

Chapters 2 & 6 (Textbook Notes)

6 Pages
Unlock Document

University of Toronto Scarborough
Suzanne Erb

PSYC62: Drugs and the Human Brain Midterm Notes (Chapters 2 & 6) Professor Suzanne Erb Chapter #2: Basic Principles of Pharmacology - 9Z Z}o}2] o Z}Z Z}}] 2ZL}L9]L[ZZlZ]L27Z}2 ZL2Z ]]]Z]L -^7 route of administering drug, amount of drug administered, how frequently drug is taken, etc. - Drug = no specificmedical definition o Any substance used in chemistrymedical practices o Any agent used in medicine or ingredients in medicine o Narcotic agent or illicit substance o General def = chemical that affects 1+ biological processes J but not all substances that affect biological processes are considered drugs (e.g. carbs, vitamins, nutrients, etc.) - ^::}ZL[ZJ})]ZoKLZ}LZZZoL]ZZLJ not classified as a drug tho ~o }Z}olZL}oLL] }]LL[ }LZ]Z2Z[]Z - Chemicals originatingproduced win organism used to carry out normal biological functions in body not usually oZZ]]Z2Z[ o Known as endogenous substances (drugs = exogenous substances) - Drug = nonfood chemical that alters 1+ normal biological processes in living organism - Drug dose = quantity of drug administered at 1 time J unit of drugbody weight of org (e.g. mgkg) - Drug dosage = administrations of drugunit of time (e.g. 10 mgkg 4xday for 3 days) Drug Effects - Pharmacodynamics = biochemical and physiological effects of drugs and mechanisms of action - Drugs act at specific site in body = receptors o Large (protein) molecules where ligands (active chemicals) induce their effects o Chemicals bind to receptors J can then become activated Binding is usually temporaryreversible J when it leaves the receptor, it disassociates - Affinity = relative capacity of compound to maintain contact w or be bough to a receptor - Efficacy = degree of biological activityrelative capability of a compound to activate receptor after it is bound - Affinity and efficacy are independent but usually without affinity, not much efficacy - Each neuroactive ligand in NS has several diff types of receptors on which in acts J each w own separate function J drugs can mimic ligands - Agonists = compounds w both affinity for and capability of activating a receptor - Sometimes drugs enhance the amount of endogenous ligands available for receptor = indirect agonist - Antagonists = drug exerts effect by blocking the action of an agonist - Partial agonist = drugs that display intermediate efficacy in receptor activation between efficacy of full agonist and antagonist o Can sometimes have greater affinity than a full agonist but will not achieve maximal response of full agonist J therefore reduces effects of full agonist seeing as full agonist cannot bind to receptor - Inverse agonist )2 ZZZK }Z2}L]Z} Z }}Z]}2}L]Z[ZJ still viewed as an agonist - Mixed agonist-antagonist = drug acts as agonist by itself but blocks the activity of another agonist in the same system www.notesolution.com
More Less

Related notes for PSYC62H3

Log In


Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.