Textbook Notes (368,241)
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Psychology (9,695)
PSYC62H3 (313)
Chapter 2&6

Chapters 2 & 6 (Textbook Notes)

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Suzanne Erb

PSYC62: Drugs and the Human Brain Midterm Notes (Chapters 2 & 6) Professor Suzanne Erb Chapter #2: Basic Principles of Pharmacology - 9Z Z}o}2] o Z}Z Z}}] 2ZL}L9]L[ZZlZ]L27Z}2 ZL2Z ]]]Z]L -^7 route of administering drug, amount of drug administered, how frequently drug is taken, etc. - Drug = no specificmedical definition o Any substance used in chemistrymedical practices o Any agent used in medicine or ingredients in medicine o Narcotic agent or illicit substance o General def = chemical that affects 1+ biological processes J but not all substances that affect biological processes are considered drugs (e.g. carbs, vitamins, nutrients, etc.) - ^::}ZL[ZJ})]ZoKLZ}LZZZoL]ZZLJ not classified as a drug tho ~o }Z}olZL}oLL] }]LL[ }LZ]Z2Z[]Z - Chemicals originatingproduced win organism used to carry out normal biological functions in body not usually oZZ]]Z2Z[ o Known as endogenous substances (drugs = exogenous substances) - Drug = nonfood chemical that alters 1+ normal biological processes in living organism - Drug dose = quantity of drug administered at 1 time J unit of drugbody weight of org (e.g. mgkg) - Drug dosage = administrations of drugunit of time (e.g. 10 mgkg 4xday for 3 days) Drug Effects - Pharmacodynamics = biochemical and physiological effects of drugs and mechanisms of action - Drugs act at specific site in body = receptors o Large (protein) molecules where ligands (active chemicals) induce their effects o Chemicals bind to receptors J can then become activated Binding is usually temporaryreversible J when it leaves the receptor, it disassociates - Affinity = relative capacity of compound to maintain contact w or be bough to a receptor - Efficacy = degree of biological activityrelative capability of a compound to activate receptor after it is bound - Affinity and efficacy are independent but usually without affinity, not much efficacy - Each neuroactive ligand in NS has several diff types of receptors on which in acts J each w own separate function J drugs can mimic ligands - Agonists = compounds w both affinity for and capability of activating a receptor - Sometimes drugs enhance the amount of endogenous ligands available for receptor = indirect agonist - Antagonists = drug exerts effect by blocking the action of an agonist - Partial agonist = drugs that display intermediate efficacy in receptor activation between efficacy of full agonist and antagonist o Can sometimes have greater affinity than a full agonist but will not achieve maximal response of full agonist J therefore reduces effects of full agonist seeing as full agonist cannot bind to receptor - Inverse agonist )2 ZZZK }Z2}L]Z} Z }}Z]}2}L]Z[ZJ still viewed as an agonist - Mixed agonist-antagonist = drug acts as agonist by itself but blocks the activity of another agonist in the same system www.notesolution.com
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