BIO130H1 Chapter Notes - Chapter 12.3: Histone H2A, Mitosis, H2Afx
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BIO130H1 Full Course Notes
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Document Summary
Have undergone very little change over evolutionary time. Since the +vely charged histones interact with the -vely charged backbone of the dna. Nearly all of the amino acids in a histone molecule are engaged in an interaction with another molecule, either dna or another histone. H2a. x replaces conventional h2a in a fraction of the nucleosomes. H2a. x becomes phosphorylated at sites of dna strand breakage and may play a role in recruiting the enzymes that repair the dna. Higher levels of chromatin structure: when chromatin is released from nuclei and prepared at physiologic ionic, if, for example, h1 linker histones are selectively extracted from compacted filament shown. Helps with high order structure and packaging of chromatin strength, a fiber of approximately 30 nm thickness is observed (still remains chromatin, the 30 nm fibers uncoil to form thinner, more extended beaded. Protein called cohesion helps with maintain these loops: basically, Nucleosomes are fibers, which in turn are organized into looped domains.
