The rapid pace of scientific advances is enabling understanding of disease at a molecular level, this leads to technical and regulatory challenges due to more difficult science which poses higher risks. Overall the probability of clinical success of the drug at hand is 12% Personalized medicines are dependent on ones molecular profile and genetic makeup faster diagnosis + fewer side effects. This is more complex and thus clinical trial protocol must be modified and enhanced: patient population identified to responded targeted therapies is lower and more difficult to attain. The investigators conduct studies in cells, tissues and animal models to determine weather the target can be influenced by a medicine. Target validation is crucial to help scientists identify the most promising approaches before going into the laboratory to develop potential drug candidates, increasing the efficiency. After understanding the disease pathway researchers investigate different compounds leading to the one compound (a molecule that could influence the target). i.