BI110 Chapter Notes - Chapter 33: Contact Inhibition, Telomere, Signal Transduction
Document Summary
Module 33 regulaion of the cell cycle. Cell cycle is controlled by complexes of cyclins together with cyclin-dependent protein kinases (cdks) Cdks: only acivated when combined with a cyclin, add phosphate groups to target proteins when acivated by a cyclin. Diferent cyclin: cdk combinaions regulate cell cycle transiions at diferent checkpoints . Adding phosphate groups since it"s a kinase (phosphorylate target protein: important for cell to progress to next stage of cycle. Progression through the cell cycle is controlled by checkpoints. Cells that do not divide do not pass the g1 checkpoint and remain in g0. G1 checkpoint, it usually commited to complete mitosis. Cells with dna or chromosome damage will fail to pass the g2 or m checkpoints. M checkpoint not passed unil spindle atached to kinetochores. G1 is thought to be most important. G1 dna synthesis cell prepares for division g2 cell divides (mitosis) m cytokinesis. Class of proteins whose concentraion depends on cell cycle phase.
