PS268 Chapter Notes - Chapter 18: Nicotine Replacement Therapy, Smoking Cessation, Reuptake
Document Summary
5 nicotine replacement therapies have been approved to treat nicotine dependence: transdermal nicotine patch, nicotine gum, nicotine vapour inhaler, nicotine spray, nicotine lozenge. All these treatments have been demonstrated to increase quit rates but its harder to quit with no monitoring or plan. Bupropion (zyban) was approved for nicotine quitting in 1998 and is also used in the treatment of depression where is is called wellbutrin. Believed to be the inhibition of dopamine and norepinephrine reuptake and the blockade of acetylcholine receptors that play a role in zyban"s usefulness. Unlike with nicotine replacement therapies, there is no requirement for smoker to abstain from use of nicotine containing products while on bupropion. Studies show the nicotine patch plus lozenge together produces greatest benefit. Combining nicotine substitution with bupropion doesn"t make much more difference. Found more effective than placebo or bupropion and is a viable option for smoking cessation therapy.
