BIOL 2021 Chapter Notes - Chapter 15.8: Receptor Tyrosine Kinase, Growth Factor, Tyrosine
Document Summary
Receptor tyrosine kinase (rtk): similar to gpcrs. Both transmembrane proteins that bind to a ligand on the outer surface of the pm and can sometimes activate the same pathways as gpcrs. Different because the cytosolic domain has enzymatic activity or associates with an enzyme and only have 1 transmembrane domain (not 7) Q: gpcrs often activate some of the same signaling pathways. Egf (epidermal growth factor), insulin, ngf (nerve growth factor) which are responsible for cell survival, growth, and division. Ligands can also be proteins on another cell. Ex. ephrin: development of cells (contact-dependent signaling) Get activated by docking sites: the ligand binds, the 2 receptors come together (dimerize) and transautophosphorylation occurs: receptors phosphorylate each other, they then generate binding sites for signaling proteins to bind. 2 effects of transautophosphorylation: increase kinase activity of receptor (activation of the domains, create docking sites for other signal proteins. This is a signaling complex and docking or phosphorylation activates the proteins.