PHIL 2015 Chapter Notes - Chapter 3: Risperidone, Benzisoxazole, Atypical Antipsychotic
6 May 2020
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Information to be discussed with patient: name, strength and dosage form of medication. 1 mg in oral wafer: condition: schizophrenia, risperidone is a benzisoxazole atypical antipsychotic with mixed serotonin-dopamine antagonist activity that binds to 5- Ht-receptors in the cns and in the periphery with a very high affinity; binds to dopamine-d2 receptors with less affinity. The binding affinity to the dopamine-d2 receptor is 20 times lower than the 5-ht2 affinity. The addition of serotonin antagonism to dopamine antagonism (classic neuroleptic mechanism) is thought to improve negative symptoms of schizophrenia: family: antipsychotic. Can be administered on either a o. d. or b. i. d. schedule, generally beginning with 1 to 2 mg per day. The dose should be adjusted gradually over several days based on clinical response to a target dose of 4 to 6 mg per day. Some patients may benefit from lower initial doses and/or a slower adjustment schedule.
