PSC 432 Chapter Notes - Chapter 32: Idiopathic Intracranial Hypertension, Prokaryotic Small Ribosomal Subunit, Intracranial Pressure
17 Feb 2019
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As broad spectrum, bacteriostatic antibiotics, the tetracyclines are effective against gram. Mg2+-dependen efflux mechanism, enzymatic inactivation and production of proteins. Absorption: all tetracyclines are adequately but incompletely absorbed after oral. Dairy foods decrease their absorption due to formation of nonabsorbable chelates of the: mechanism of action. Entry of these agents into susceptible organisms is mediated both by passive diffusion and by an energy dependent transport protein mechanism unique to the bacterial inner cytoplasmic membrane. Typical uses; g+ rod; b. anthracis, g- rods; brucella spp, v. cholera, y. pestis, Anaerobes; c. perfringens, c. tetani, spirochetes; b. burgdorferi, l. interrogans, others; m. Pneumoniae, chlamydia spp and rickettsiae: resistance that prevent binding to 30s subunit, pharmacokinetics ingestion. tetracyclines with calcium ions. patients, because it is preferentially excreted via the bile into the feces. Others are excreted via kidneys: adverse effects calcification in growing children.
