BIOL-2110 Chapter Notes - Chapter 12: Risk Assessment, Exposure Assessment, Bioaccumulation

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4 Dec 2017
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Risk: probability that hazard will cause adverse effect under specific exposure to chemical. Hazard: capability of a substance to cause adverse effect. Safety: certainty that adverse effects will not occur when a substance is used. Risk assessment: process where hazard, exposure and risk are determined. Risk assessment is carried out on chemicals for the following reasons: The chemical is hazardous to humans in the environment. Likelihood of persistence of chem in environment and bioaccumulation. Likelihood that sensitive human and ecological pops may be exposed to significant levels. Hazard identification: evaluation of toxic effects of the chemicals. Demonstration of dose response or dose effect relationships. Exposure assessment: determine level, frequency and duration of exposure of humans to the hazardous substance. Risk characterization: estimation of incidence of adverse effects under. Risk characterization: estimation of incidence of adverse effects under various conditions. Evaluation of potential of chemical that causes toxicity. In vivo and in vitro mechanistic or other studies.

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