BIOL 1201 Chapter : BIOL 1201 2 23
Document Summary
2/23/2012 3:43:00 pm: bacteria-thermophiles exist at temperatures up to 132 degrees. Regulation of enzyme activity: how are enzymes controlled, can they be turned off and on, modulation of activity, binding of ligands, covalent modification. Competitive enzyme inhibition: substrate and inhibitor compete for binding to the active site of the enzyme, inhibitor is structurally similar to the substrate, most apparent at low [substrate] Noncompetitive enzyme inhibition: inhibitor binds at a site away from the substrate binding site, causes a conformational change in the enzyme, not overcome by increasing the [substrate] Another control problem: some processes require energy and reducing power , some produce energy and reducing power , some break down biological molecules, some build biological molecules. Spatial separation: separate processes which are conflicting, e. g. in organelles, mitochondria, site of respiration, produce energy, lysosome, isolate digestive enzymes from the proteins in the cytoplasm. Catabolic and anabolic reactions: catabolism is exergonic, anabolica processes require the input of energy.
