PSYC414 Chapter Notes - Chapter 5: Drug Withdrawal, Cell Group, Electrophysiology

• School: University of Delaware
• Department: Psychology
• Course: PSYC414
• Professor: Jeffery Rosen

Document Summary

Central noradrenergic system cell bodies are found in the brain stem and ascending fibers innervate forebrain structures. Ne released from these cells acts on adrenergic receptors located either in the cns or peripheral target organs. Ne is an important transmitter in both cns and pns. Located in pons and medulla of the brainstem. Ne and epi act through alpha- and beta-adrenergic receptors. Receptors of ne and epi= adrenergic receptors (adrenoceptors) Mediate both nt (ne) and hormonal (epi) actions of the catecholamines. Early studies : existence of 2 adrenoceptor subtypes designated as alpha and beta, composed of those two families with subtype. Postsynaptic adrenoceptors foundin high densities in cerebral cortex, thalamus, hypothalamus, cerebellum, limbic system structures, etc. Alpha2 autoreceptors- located on noradrenergic nerve terminals and cell bodies of noradrenergic neurons in the lc and elsewhere. Inhibition of noradrenergic cell firing and reduction in ne release from terminals. Beta 1 and 2 adrenoceptors stimulate adenylyl cyclase and enhance camp formation.