BSC 2010 Chapter Notes - Chapter 9: Dna Mismatch Repair, Sickle-Cell Disease, Deamination
22 Mar 2016
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Virtually all nondividing somatic cells of an organism have the same amount of nuclear dna. After meiosis, gametes have half the amount of nuclear dna as somatic cells. Transgenic- when a new multicellular organism forms through mitosis. Rosalind franklin helped us find out the helical structure of dna. Chargraff: dna from many different species had similarities, amount of adenine = amount of thymine (and same for c and g) Watson and crick: double helix shape of dna, helical- must have a spiral shape like a spring, antiparallel- strands run in opposite directions, the nucleotide bases are on the interior of the two strands. The sugar-phosphate backbone is on the outside. 4 key features define dna structure: dna is a double-stranded helix of uniform diameter, the two dna strands are antiparallel. The 5" end of the chain is a free phosphate group.
