MCB 354 Chapter Notes - Chapter Ch 1 pg 12-29: Molecular Configuration, Metabolome, Stereoisomerism
3 Sep 2018
School
Department
Course
Professor
Document Summary
Breakdown of glucose in yeast and muscle cells involved the same ten chemical intermediates. 30 of the 90+ elements are essential to organisms. H, o, n, c make up more than 99% of the mass of most cells. Biomolecules are compounds of carbon with a variety of functional groups. 50% dry weight of cells = c. Carbon can form very stable c-c bonds. Single bonds: angle = 109. 5 deg, length = . 154 nm, flexible. Double bonds: angle = 180 deg, length = . 134 nm, rigid. C"s versatility was major factor in selection of c compounds for molecular machinery. Cells contain a universal set of small molecules. All cells contain 100-200 different small organic molecules (central metabolites) Universal occurrence of same set of compounds is manifestation of universality of metabolic design. Secondary metabolites = small molecules specific to certain types of cells/organisms. Metabolome = entire collection of small molecules in a given cell. Macromolecules can be complexed into supramolecules (ribosome)
