BIOCHEM 423 Chapter Notes - Chapter 12.3: Isozyme, Tetrameric Protein, Decarboxylation

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viridianhornet922

7 Dec 2018

School

UMASS-Amherst

Department

Biochemistry & Molecular Bio.

Course

BIOCHEM 423

Professor

Ma Fu

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Document Summary

25 moles of atp per mole ot nadh oxidised ( mitochondrial electron transport chain : lactate metabolism. Undergoing very high ratesof glycolysis , the nadh generated in reaction 6 of glycolysis cannot all be re oxidized to nan at comparable rates in mitochondria. I kj true: pyruvate must be reduced to lactate when tissues are insufficiently aerobic to oxidize all of the nadh formed in glycolysis . Ldh is a tetrameric protein consisting of two types of subunits. The tissue specificity of isozyme patterns is useful in clinical medicine . ( af. N , h combine randomly with each other . Levels of the genes specifying the two subunits . on. C coenzyme for all decarboxylation s of a - keto acids ) am connection " Acetaldehyde is quite toxic and many of the unpleasant etat of hangovers , such as headache or nausea , result from an accumulation of acetaldehyde .

Related Questions

Question 1

Which of the following statements regarding photosynthesis and cellular respiration is true?

	A.	Photosynthesis occurs in mitochondria, and cellular respiration occurs in chloroplasts.
	B.	Photosynthesis occurs in chloroplasts, and cellular respiration occurs in mitochondria.
	C.	Photosynthesis occurs in mitochondria and in chloroplasts.

Question 2

How do cells capture the energy released by cellular respiration?

	A.	They produce glucose
	B.	The energy is coupled to oxygen
	C.	They produce ATP

Question 3

During redox reactions

	A.	the loss of electrons from one molecule is called reduction
	B.	electrons are lost from one substance and added to another substance
	C.	protons from one molecule replace the electrons lost from another molecule

Question 4

Oxidation is the ________, and reduction is the ________.

	A.	gain of oxygen; loss of oxygen
	B.	loss of electrons; gain of electrons
	C.	gain of protons; loss of protons

Question 5

During cellular respiration, NADH

	A.	delivers its electron load to the first electron carrier molecule.
	B.	is chemically converted into ATP
	C.	is the final electron acceptor

Question 6

A drug is tested in the laboratory and is found to create holes in both mitochondrial membranes. Scientists suspect that the drug will be harmful to human cells because it will inhibit

	A.	the citric acid cycle only.
	B.	glycolysis only
	C.	the citric acid cycle and oxidative phosphorylation

Question 7

Which of the following metabolic pathways is common in aerobic and anaerobic metabolism?

	A.	glycolysis
	B.	the citric acid cycle
	C.	electron transport chain

Question 8

Which of the following is a result of glycolysis?

	A.	production of CO2
	B.	a net loss of two ATPs per glucose molecule
	C.	conversion of glucose to two three-carbon compounds

_____What is added to a molecule such as ADP when it is phosphorylated?

_____ An anaerobic process in which pyruvate is converted to lactate

_____ A biochemical process that breaks down food molecules to produce other molecules for cellular maintenance.

_____What is the final end product of Glycolysis?

_____ Refers to the potential energy provided by a large hydrogen-cation concentration gradient, and itâs movement across a biological membrane during chemiosmosis.

_____ A molecule that transfers or shuttles electrons during redox reactions.

_____ An organism that can survive in the presence or absence of oxygen.

_____ A type of enzyme that teams with NAD⁺ to remove hydrogen atoms with their electrons.

_____ The loss of electrons from one molecule to another.

_____ A process in which ATP is produced using the energy stored in concentration gradients.

_____ The products produced during a biochemical reaction that fall between the starting molecule and the end product.

_____ Biochemical process in which a glucose molecule is degraded to two pyruvates.

_____ Short for âreduction/oxidationâ reactions

_____How many pyruvate molecules are produced from a single Glyceraldehyde 3-phosphate?

_____ The formation of ATP occurring when an enzyme transfers a phosphate group from an organic molecule to ADP.

_____ Organisms that will die in the presence of oxygen.

_____ A term referring to the presence of oxygen.

_____ A series of electron-carrier molecules that shuttle electrons during the redox reactions that release energy used to make ATP.

_____ A biochemical process in which pyruvate is produced without the presence of oxygen.

20._____ The metabolic cycle that is fueled by Acetyl CoEnzyme A; occurs in the matrix of the mitochondria and supplies most of the NADH molecules that carry energy to the electron transport chain.

_____What is the chemical formula for Cellular Respiration?

_____What environmental condition is necessary for Anaerobic Respiration to occur?

_____Where does the Electron Transport Chain occur in the mitochondria?

_____Where does Glycolysis occur in a cell?

_____ An anaerobic process in which CO₂ is released as a byproduct and ethanol is produced as a product.

_____Where does the Krebs cycle occur in the mitochondria?

_____ The gain of electrons from one molecule to another.

_____ A high-energy fuel molecule that begins the Citric Acid Cycle.

_____What condition is necessary of Aerobic Respiration to occur?

_____ A term referring to the absence of oxygen.

_____What compound is derived from B vitamins, and helps the Acetyl portion of Acetyl CoA into the Krebs Cycle?

_____What is the name of the molecule that channels protons, providing the energy necessary to phosphorylate ADP to ATP?

_____In the blank, write the number of ATP^âs that can be synthesized from 3 NADH molecules.

_____In the blank, write the number of ATP^âs that can be synthesized from a single FADH₂ molecule.

_____What is the final electron acceptor in cellular respiration?

_____What molecule is regenerated during the process of the Krebs Cycle?

_____What enzyme is used to catalyzed the reaction that occurs during the formation of Acetyl CoA?

_____How many pyruvates are produced from a single glucose molecule?

_____How many Acetyl CoA molecules are produced from a single glucose molecule?

_____What is the reduced form of Nicotinamide Adenine Dinucleotide?

_____What is the oxidized form of Flavin Adenine Dinucleotide?

42._____ A membrane protein that is used in conjunction with chemiosmosis to produced ATP.

I know that this alot of questions, but it's kinda a last ditch effort. these are the last 42 definitions i have left to answer out of 500 question for my final exam study guide. so whatever help i can get is fine. No explanations needed just what each definition is explaining and thanks in advance ladies and gentlemen.

scarletlocust623

A catabolic pathway would predictably result in the
A) reduction of a sugar.
B) synthesis of a macromolecule.
C) breakdown of a macromolecule.
D) breakdown of an atom.
2.
The drug Ritonavir is used to treat people with HIV/AIDS. It worksby binding to the active site of HIV-1 protease, an enzyme used bythe AIDS virus to create new proteins for production of newviruses.Once bound, the HIV-1 protease cannot produce proteins.Ritonavir can be classified as a(n)
A) competitive inhibitor.
B) allosteric inhibitor.
C) activator.
D) non-competitive inhibitor.
3.
During cellular respiration, __________ is the final electronacceptor that allows the regeneration of the cellâs supply of NAD+.In fermentation, ____________ is the final electron acceptor forNAD+ regeneration.
A) pyruvate / lactic acid
B) pyruvate / oxygen
C) ethanol / CO2
D) oxygen / pyruvate
4.
Which of the following clues would tell you if a cell isprokaryotic or eukaryotic?
A) whether or not the cell carries out cellular metabolism
B) the presence or absence of ribosomes
C) whether or not the cell is partitioned by internalmembranes
D) whether or not the cell contains DNA
5.
Phosphofructokinase (PFK) is an allosteric enzyme that regulatesglycolysis. When cellular concentrations of ATP and citrate become__________, this enzymeâs activity decreases. When cellularconcentrations of AMP become ________, the enzyme isactivated.
A) high / high
B) high / low
C) low / high
D) low / low
6.
______________ is an enzyme that can utilize the free energy in thehydrogen gradient (voltage) produced between the inner and outermembrane of the mitochondrion. The enzyme uses this energy toproduce ________.
A) ATP synthase/ ATP
B) PFK/ ATP
C) PFK/ glucose
D) ATP synthase/ ADP
7.
ATP is able to do cellular work because it
A) has a high energy phosphate bond that can be hydrolyzed torelease energy.
B) converts light energy into chemical bond energy.
C) contains the sugar ribose, which can provide additional energyfor a cell.
D) its hydrolysis is endergonic.
8.
A solution of starch at room temperature does not readily decomposeto form a solution of simple sugars because
A) the starch solution has less free energy than the sugarsolution.
B) the activation energy barrier for this reaction cannot besurmounted.
C) the hydrolysis of starch to sugar is endergonic.
D) starch hydrolysis is nonspontaneous.
9.
A person exposed to toxins would have more activity in their___________compared to an unexposed person.
A) lysosomes
B) Golgi bodies
C) rough endoplasmic reticulum
D) smooth endoplasmic reticulum
10.
Which of the following statements about fermentation is true?
A) The function of fermentation is to regenerate the fermentingcells' supply of NAD+.
B) Fermentation allows a fermenting cell to gain more energy perglucose molecule than a non-fermenting cell.
C) Fermentation produces either lactic acid or ethanol that thefermenting cell can use as an energy source.
D) Fermentation is a universal process that occurs in all cells andall organisms.
11.
A glucose molecule is completely broken down to carbon dioxide andwater in glycolysis and the citric acid (Krebs) cycle, but togetherthese two processes yield only a few molecules of ATP. Whathappened to most of the energy that the cell obtains from theoxidation of glucose?
A) It was lost as heat.
B) It is stored in the carbon dioxide and water molecules releasedby these processes.
C) It is stored in the ATP that was formed by glycolysis and thecitric acid cycle.
D) It is stored in NADH and FADH2
12.
The First Law of Thermodynamics states that
A) entropy tends to increase in a system.
B) entropy tends to decrease in a system.
C) energy cannot be created nor destroyed.
D) the quality of energy in the universe is decreasing.
13.
The endosymbiotic theory states that _______________ evolved as aresult of a symbiotic relationship between different types ofbacteria. _____________ is thought to be the selective factor thatmade this symbiosis advantageous.
A) mitochondria / A change in the Earthâs atmosphere from anaerobicto aerobic
B) endoplasmic reticulum / A decrease in the amount of foodavailable in the environment
C) chloroplasts / A change in the Earthâs atmosphere from aerobicto anaerobic
D) lysosomes / A decrease in the amount of food available in theenvironment
14.
A mutation in a fruit fly affects one of the proteins that pumphydrogen ions across the inner mitochondrial membrane; thismutation makes that particular protein function less efficiently.When comparing aerobic cellular respiration in this fly with awild-type fly, you would predict that the mutant fly would
A) produce less ATP than a wild-type fly.
B) show no difference in ATP production when compared to awild-type fly.
C) produce more ATP than a wild-type fly.
D) not be able to produce any ATP via aerobic cellularrespiration.
15.
Proteins that are destined to be exported from the cell have unique_________________ that are recognized by signal recognitionparticles and thus moved to the _________________ duringtranslation.
A) phosphofructokinases / nucleus
B) codons / rough endoplasmic reticulum
C) signal recognition sequences / rough endoplasmic reticulum
D) signal recognition sequences / free ribosomes
16.
During the Krebs cycle
A) NADH is oxidized.
B) ATP is produced.
C) pyruvate is produced.
D) Acetly CoA gains a carbon to form pyruvate.
17.
Why does the oxidation of organic compounds by molecular oxygen toproduce CO2 and water release free energy?
A) Electrons are being moved from atoms that have a lower affinityfor electrons (such as C) to atoms with a higher affinity forelectrons (such as O).
B) The electrons have a higher potential energy when associatedwith water and CO2 than they do in organic compounds.
C) The covalent bond in O2 is unstable and easily broken byelectrons from organic molecules.
D) The covalent bonds in organic molecules and molecular oxygenhave more kinetic energy than the covalent bonds in water andcarbon dioxide.
18.
In a chemical reaction, if ?G is negative, it means that thereaction is
A) exergonic, and work needs to be done for the reaction toproceed.
B) exergonic, and work can be done with energy released from thereaction.
C) endergonic, and work needs to be done in order for the reactionto proceed.
D) endergonic, and work can be done with energy released from thereaction.
19.
The energy for an endergonic reaction comes from a(n) ___________reaction.
A) ADP + P --> ATP
B) endergonic.
C) exergonic.
D) anabolic
20.
Glycolysis
A) involves catabolic reactions and ATP is produced.
B) involves anabolic reactions and ATP is produced.
C) involves catabolic reactions and creates energy.
D) involves anabolic reactions and creates energy.

BIOCHEM 423 Chapter Notes - Chapter 12.3: Isozyme, Tetrameric Protein, Decarboxylation

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