BIOCH200 Lecture Notes - Lecture 30: Pyruvate Dehydrogenase Complex, Pyruvate Dehydrogenase, Acetyl-Coa
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4 Dec 2016
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Biochem 200 - lecture #30 - fates of pyruvate. Glucose metabolism: most oxidized form is carbon dioxide. Fates of pyruvate: pyruvate can be converted to alanine (and vice versa) Why is an anaerobic fate for pyruvate required: to regenerate nad+ (from nadh) for the oxidation reaction in glycolysis under. 2 atp net: nadh needs to be reoxidized to nad+ for glycolysis to continue. The production of lactate: lactate is not an acid. It is a dead-end product in the skeletal muscle. Can export it out or convert it back into pyruvate. Lactate is exported from the muscle via a specific membrane transporter protein: the lactate and proton transport is a symport transport. Bloodstream ph levels will decrease: how might lactate transport be beneficial to an athlete. O2 release to tissues that are oxygen depleted. Does not (cid:1373) ph of muscle cells though: atp (cid:1372) adp yields h+
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