BIOL10004 Lecture Notes - Lecture 7: Cellular Respiration, Endergonic Reaction, Exergonic Reaction

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BIOL – Lecture 7
Respiration
Energy
• chemical and energy transformation in cells
o metabolism
• sequence of chemical reactions
o metabolic pathways
• energy is the capacity to do work
o potential energy is stored energy
o kinetic energy is expressed as movement
• energy transformations are governed by the laws of thermodynamics
o complex systems require energy to build and maintain
o and energy is conserved – it ist destroed
harvesting chemical energy
• organisms convert chemical energy of fuel molecules to useable energy in the form
of ATP (ATP is used to drive cellular processes)
• energy is released along metabolic (catabolic) pathways
o CHOs processed by glycolysis - faster
o Lipids processed by Ăź-oxidation - slower
• Products of these pathways act as substrates for cellular respiration
o Glycolysis, fermentation, krebs cycle, ETC
ATP
• Energy released from an exergonic reaction is used to phosphorylate ADP, which is
then dephosphorylated to drive an endergonic reaction
Enzymes
• Enzymes are biological catalysts that
lower the activation energy in
reactants (substrates)
o Enzyme- catalysed reactions
require less activation energy
o They proceed thousands of
times faster
Enzyme catalytic cycle
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Electron transport pathways
• Enzymes for particular pathways are often physically linked – substrate channelling
o Because they occur in sequence so need to be close - efficiency
• Electrons are transferred from donor to acceptor
o Molecule that loses electron is oxidised
o Molecule that gains electron is reduced
• Transfer reactions are oxidation-reduction reactions (redox)
Overview of cellular respiration
Glycolysis: initial processing of glucose
• Occurs in cytosol
• Net producer of energy – not much though – net 2 ATP
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Document Summary

Atp: energy released from an exergonic reaction is used to phosphorylate adp, which is then dephosphorylated to drive an endergonic reaction. Enzymes: enzymes are biological catalysts that lower the activation energy in reactants (substrates, enzyme- catalysed reactions require less activation energy, they proceed thousands of times faster. Glycolysis: initial processing of glucose: occurs in cytosol, net producer of energy not much though net 2 atp. Intermembrane space between inner and outer membranes, matrix within inner membrane: the interplay between what happens in intermembrane space and matrix is important in understanding cellular respiration. Krebs cycle: completing the oxidation of fuels: turns twice for each glucose molecule (once for each of the 2 pyruvates) Action of atp synthase: channel allows h+ to move freely down electrochemical gradient, movement is source of energy of atp synthesis, every 3 h+ that cross provide enough energy to form one atp.

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