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Lecture

BIOL 1F25 - Lec 9

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Department
Biology
Course
BIOL 1F25
Professor
Nicholas D Vesprini
Semester
Winter

Description
Lecture 9 Pre-post coincidence mechanism -proposed by Donald Hebb in 1949 -coincident activity in pre and post synaptic cells is critical for strengthening the connection between them -if cells 1 and 2 are firing action potentials at the same time (but not cell 3), only the connection between cells 1 and 2 will be strengthened (but not between 2 and 3) How does increased synaptic strength occur? 1. Molecular changes 2. Morphological (structural) changes -often studied in CA3 to CA1 pathway in hippocampus but can also occur in many other brain areas -Areas CA3 and CA1: different groups of cells located in the hippocampus -CA3: pre-synaptic cell; sends message to CA1 neuron -CA1: post-synaptic cell; synapse uses glutamate (excitatory transmitter) Post-synaptic changes -more glutamate receptors put into post-synaptic membrane; allows bigger response to transmitter -pre-synaptic changes: enhanced transmitter release (glutamate) -both these effects lead to increase in synaptic strength that can last for many hours; i.e. long
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