BIOL 1F25 Lecture Notes - Lecture 10: Long-Term Potentiation, Vise, Donald O. Hebb
21 Jan 2016
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Document Summary
Lecture 10: cellular mechanisms of learning and memory. Important to form new factual and special memories. Ltp, cellular change in hippocampus: happened strongly in hippocampus, changes lasted for a long time. Long term potentiation (ltp): first reported by bliss and lomo in 1973 as an enhancement of synaptic transmission. An increase in strength of a synapse following learning. Synaptic vesicles fuse with membrane and release chemical transmitters. Transmitters bind to receptors on receiving cell and message is transferred. How can a synapse change? increased or decreased: amount of transmitter released can be increase or decreased, amount of receptors present on post-synaptic cell can be. *if synapse is strengthened, more release of transmitters. *number of receptors can vary (larger signal-receptor numbers will go up, and vise versa for smaller signals) *if in the brain, it wanted to strengthen-get cell to release more message or get brain to release more transmitters.
