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Lecture 25

BIOL 1F90 Lecture Notes - Lecture 25: X-Inactivation, Barr Body, Genomic Imprinting


Department
Biological Sciences
Course Code
BIOL 1F90
Professor
Fiona Hunter
Lecture
25

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End of Chapter 15
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Imprinted genes do not follow Mendelian patterns of
inheritance (distinguishing what you got from mom and
what you got from dad, not random, either one from mom
or dad but not both, have less (maternal or paternal) )
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$#$##$#!!-$#)#
(7!)83)#-"
!$!>###)$#
!&#$#!&##))
!.##.)-*3))
!*
Normal and dwarf o!spring can have the same genotype
but di!erent phenotypes
"#)$() !7
)$-##!!!8
The maternal Igf-2 is methylated and cannot be
transcribed
A male can inherit a methylated gene from his mother
that is never transcribed but he can pass on an active,
nonmethylated copy of this exact same gene to his
o!spring
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