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Lecture 9

BIOL 2P03 Lecture 9: Week 9 Screencast - Intermediate Filaments
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Department
Biology
Course
BIOL 2P03
Professor
Mark K Lukewich
Semester
Winter

Description
BIOL 2P03 Week 9 Screencast – Intermediate Filaments th th March 13 – March 19 , 2017 Intermediate Filaments Overview • Part of the cytoskeleton • Intermediate thickness compared to microfilaments (thinnest) and microtubules (thickest) • Present throughout the cytoplasm • Also line inner nuclear envelope • Made up of many different types of fundamental subunits • Much more diverse than microfilaments and microtubules • Often expressed in tissue-specific manner • Do not possess an intrinsic polarity • Subunits do not bind to nucleotides • No known nucleating or capping proteins • No known motor proteins associated with intermediate filaments Intermediate Filament Assembly • There are many different types of subunits that can assemble into intermediate filaments – The way in which these subunits assemble is very similar though • Subunits will spontaneously assemble in vit
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