BIOL 3P30 Lecture Notes - Lecture 28: Phosphodiesterase, Phosphofructokinase, Glucagon
22 Aug 2015
School
Department
Course
Professor
Document Summary
Vr (where vf catalyzed by pfk, vr. Take a case where there is a 4 fold increase in amp with vigorous exercise. Key: vmax of pfk is ~ 10 times that of fbpase. 90% vmax 10% vmax vmax 10 catalyzed by fbpase) If look at combined reactions of pfk and fbpase: Therefore almost a 90x increase in flux due to substrate cycling and 10% change in. F-6-p + atp f 1,6p + adp. Originally called a futile cycle because it initially appeared to result in useless consumption of atp, prior to understanding its important consumption of atp. Bumble bees make use of this futile cycle to generate heat required to fly -need thoracic temp of. 30 c, can still fly at ambient temp of 10 c. How? upon atp hydrolysis released as heat cycling (in muscle and liver) Reciprocal kinetic control of glycolysis and gluconeogenesis gluconeogenesis are: Mammals can generate some heat known as non-shivering thermogenesis via substrate.
