BIOC 4403 Lecture Notes - Lecture 25: Zygote, Heterochromatin, Histone Deacetylase

• School: Dalhousie University
• Department: Biochem & Molecular Biology
• Course: BIOC 4403
• Professor: Archibald John

Document Summary

Any process that allowed a particular phenotypic state to be inherited without changes in the sequence of dna. We"ll focus on the first two. regulation of gene expression through dna methylation, chromatin, and post-translational modification of proteins such as histones. Each pair of these element has an interaction. Biological phenomena (transcription, replication, repair, recombination, development, reprogramming, aging, tumorigenesis ) Nucleosomes serve as roadblocks to transcription. the histone tails the specific histone-dna contacts the dna sequence. The histone tails at the entry site of the nucleosome (horizontal gate) and the histone-dna contacts at the nucleosome dyad (stop sign). H2a, h2b, h3 and h4, each one x 2; dna wrapped around them twice. Linker dna, the dna exiting the nucleosome on the side and contact neighbor nucleosomes. It might be bound by linker histones like h1. Flexible histone tails, they may leave the core histone-dna complex or wrap around the. The general process of inducing changes in chromatin structure; an active process.