BIOL 2020 Lecture Notes - Lecture 14: Endoplasmic Reticulum, Endomembrane System, Nuclear Membrane

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14 Feb 2018
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Yeast sec mutants: randy and john won nobel prize. What is the endomembrane system: endoplasmic reticulum, golgi complex, endosomes. Storing in secretory vesicles: moves things out of the cell. Regulated secretory: on demand, only when there is a signal that the cell will secrete the material. Endocytic pathway: bringing materials in through endocytosis, either recycles material back to surface or digests them in the lysosome, er -> outside = anterograde direction, outside -> er = retrograde direction. Vesicle transport: as material moves from one vesicle to another, the orientation is always maintained. Some ribosomes are attached to the er and some are not: noticed that some ribosomes stay in cytosol that decode messenger rna to make protein. Signals for import into nucleus, export from nucleus, import into mitochondria, import into plastid, import into peroxisomes, import into er, return to er. Co-translational translocation mechanism: how all proteins are getting secreted out of cell and how they become part of the cell.

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