BIOL 2020 Lecture Notes - Lecture 10: Endomembrane System, Secretion, Drug Detoxification
Document Summary
Endomembrane system: an interconnected system of cytoplasmic membranes. Even though they are distinct organelles with distinct functions, they form an interconnected network where materials (proteins and membranes) are shuttled from one organelle to the other. Sometimes the movement goes out of the cell: biosynthetic or secretory pathways, er golgi various locations. Biosynthetic materials (proteins) are transported in an outwards direction from the er to the golgi to the pm or the lysosomes. Sometimes the movement comes in the cell: endocytic pathways, plasma membrane endosomes usually lysosomes. The endocytic moves materials in the opposite direction: from the plasma membrane to the endosome, which will usually then fuse with the lysosomes. The er is a folded, membranous structure that is found closes to the nucleus. It comes in two flavours smooth and rough er, marked by the presence/absence of ribosomes and by their shape.