BIOL 2030 Lecture Notes - Lecture 1: Cytogenetics, Quantitative Genetics, Molecular Genetics

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1 Introduction to Genetics
January 4th, 2016
Divisions:
Transmission genetics
Population genetics
Cytogenetics
Molecular genetics
Quantitative genetics
Genetics: Science of Heredity
Reproduction is the basis of heredity (cellular and organismal)
o Eukaryotes: unicellular or multicellular organisms with cells where genetic
material is located in the nucleus
Relatively large: 10-100um
Multiple linear DNA molecules
DNA is complexed with histones
Relatively large amount of DNA
Organelles are bound by a membrane
Cytoskeleton is present
o Prokaryotes: mostly unicellular organisms lacking a nucleus
Relatively small: 1-10um
Usually one circular DNA molecule
DNA is not complexed with histones in eubacteria; some in archea
No membrane bound organelles
Absent cytoskeleton
Some basic concepts in Genetics:
1. Gene is the fundamental unit of heredity
-A gene is…
- a unit of inheritance
- location on chromosome
- sequence of base pairs
- transcription unit
- determinant of an organic trait
-Types of Genes:
- protein-coding genes
- regulatory signal genes
- RNA encoding genes
2. Genotype is distinguished from phenotype
-genotype: the complete genetic makeup of an individual organism
-phenotype: a measurable trait of an organism that is controlled by one or more
genes but can be influenced by environmental effects **not inheritable
3. All living organisms use same genetic system
-all heredity information is encoded in nucleic acids
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