MICI 3119 Lecture Notes - Lecture 32: Nitrate Reductase, Pyruvate Dehydrogenase, Glyoxylate Cycle

• School: Dalhousie University
• Department: Microbiology & Immunology
• Course: MICI 3119
• Professor: Lee Song

Document Summary

Mici 3119 lecture 32 november 29, 2019 adaptive and environmental challenges. Outline: responses to stress, anaerobiosis, ph (acid, heat-shock, envelope stress, oxidative. Nitrate, fumarate or dmso): acetyl-coa is made by pyruvate-formate lysae (pfl) instead of pyruvate dehydrogenase (pdhg), replacement of fumarase a and succinate dehydrogenase (sdh) by fumarase b and fumarate reductase (frd), repression of -ketoglutarate dehydrogenase (odhg) synthesis. When a bacterium is changing from an aerobic to anaerobic conditions, there would be changes in metabolism. In the tca cycle, under aerobic condition, fumarate a is used and the electron is flowing using succinate dehydrogenase. Tca under anaerobic conditions: tca becomes non-cyclic and reductive because - ketoglutarate dehydrogenase (odhg) is absent, electron transport chain is altered and electrons flow to acceptors other than o2. Tca becomes non-cyclical because of the ability to undergo the glyoxylate shunt. The 2-oxoglutarate is the same as -ketoglutarate. (left) under aerobic condition, acetyl-coa is made by pdhg.